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When it comes to weight loss aids, the gold standard -- if there is one -- is prescription drugs. In addition, lipid, glycaemia and blood pressure profiles must improve. These requirements have limited the options available because, as is often the case with diet aids, there are questions about whether these modest results outweigh the potential for serious side effects even with prescription drugs.
The FDA tends to be very conservative about approving weight-loss drugs, primarily because most experts agree that obesity can best and most safely be addressed through lifestyle changes. So why not just rely on diet and exercise? In general, 5 percent to 10 percent is the magic number for clinically meaningful weight loss that lowers disease risk, and many of these drugs provide modest results when used with diet and exercise modifications.
However, these drugs may not only help patients achieve weight loss faster, research shows they may also provide a motivational boost. Doctors who treat obesity say that prescription weight loss drugs give their patients added motivation to change their behaviors long term. Since the FDA regulates diet pills, their safety is under ongoing scrutiny. As new reports of possible risks are published, the FDA will take action.
A case in point is Meridia. The FDA asked Abbott Laboratories to pull the drug in October after a New England Journal of Medicine study published in September showed that Meridia users had an increased risk of heart attack and stroke. Even though Abbott took issue with the study's methodology Abbott says many of the study's participants shouldn't have been using the drug and with its results the company says that in 46 clinical trials and 6 million patient-years of use, Meridia hasn't shown excess cardiovascular riskthey complied with the request.
The Meridia situation also shows that after long-term top 10 diet pills consumer reports in the population, issues -- such as increased disease risk -- may can you lose body fat while taking creatine to light. The bottom line: There may be some risk when taking these drugs, even though the FDA tries only to approve drugs that top 10 diet pills consumer reports deems effective and where the benefits outweigh the risks.
And, while the peril in an approved drug might be less than with unapproved diet supplements, the side effects are many. The biggest decision is whether you want to live with them. Oily stools and fecal spotting and urgency are consequences that can change the way you live. Orlistat, which is a gut lipase inhibitor, or fat blocker, is the active ingredient in the prescription-only product, Xenical. It's also the key ingredient in a somewhat controversial over-the-counter OTC product, Alli, which is 50 percent Xenical's strength.
Orlistat works by reducing the amount of fat our bodies absorb in the digestive system and eliminating it through bowel movements, which is why many of Orlistat's side effects are altered bowel activity. The suggested triggers for a patient to start using this drug are a history of failed weight loss attempts using the standard behavioral method of a smart diet and exercise regimen, and the loss of at least 2.
In addition, it is suggested that those taking Orlistat reduce their calorie consumption by to calories per day, and the amount of fat they consume to 30 top 10 diet pills consumer reports of their diet. Orlistat's side effects include oily stool, fecal spotting and urgency, diarrhea, flatulence, chronic or recurrent pain in the upper abdomen, increased abdomen fullness and indigestion.
In addition, Orlistat interferes with drugs and fat-soluble vitamins, such as A and D, which calls into question its ability to be used long term. Some critics question the usefulness of a diet drug that can be tolerated by most users only in conjunction with a low-fat diet. Xenical, as noted, is prescription only, but GlaxoSmithKline top 10 diet pills consumer reports the lower dosage version, Alli, without a doctor's prescription as part of a complete weight-loss system that incorporates the a user-support forum and an online program called MyAlli.
Because of Alli's side effects referred to as "treatment effects"potential customers are warned to assess their level of commitment to a low-fat diet before they decide to use the drug.
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